The pre-chilled slides burst chromosomes faster during the karyotyping. If you are here, trust me you haven’t found any sustancial answer for why the ‘the pre-chilled’ slides? I can imagine that you want to optimize your karyotyping protocol rather than performing it, which means you are not looking for steps and procedures of how the …
Why are we use Pre-chilled Slides in karyotyping? Read More »
Karyotyping is a process of seeing chromosomes in order to know abnormalities related to it. The metaphase chromosomes are most separatable and visible. Abnormalities in DNA or chromosomes can cause severe mental, physical or developmental disabilities. In order to find out the alteration related to chromosomes, we have to perform the cytogenetic analysis while to …
Which Cell Division Phase is Best for Karyotyping? Read More »
“Mitotic inhibitor halts cell division during karyotyping in order to get separated chromosomes. Colchicine is a common mitotic inhibitor used in cytogenetic techniques like karyotyping.” Cytogenetic techniques are used to study cell and related components. Karyotyping is a method used to analyze chromosomes during cell division hence consider as cytogenetic technique. To get good chromosomes …
“Mitogens are lectins or other peptides that bind to the cell surface and induce mitotic activity and cell division.“ By using the MAPK- mitotic activated protein kinase, a signal transduction pathway induced by mitogens leads to mitosis. The mitogens are potent endogenous or exogenous agents facilitating cell division by increasing mitotic activity. But what is …
What are Mitogens? How is it Important in Karyotyping? Read More »
A karyotype is prepared in order to study the abnormalities associated with it that are commonly known as chromosomal abnormalities or karyotyping abnormalities. Usually, karyotyping abnormalities are either structural or numerical, notably, here single base change or other smaller alteration related DNA can’t be encountered using the karyotyping. However, as we know we can count …
20 Common karyotyping (or Chromosomal) Abnormalities Read More »
Edwards syndrome is a type of chromosomal or karyotype abnormality that occurs due to the imbalance of chromosome number. During 1960, John Hilton Edwards first described the signs and symptoms of Edwards syndrome. The present genetic or chromosomal aberration is often known as T18 or trisomy 18. The mechanism known as trisomy is responsible for …
A karyotype of Patau syndrome is known as T13, is a trisomy of chromosome 13 and majorly associated with intellectual disabilities and developmental problems. Patau syndrome is not so common but still it is one of the common trisomy like the down syndrome and Edwards syndrome. Talk of the topics: in the present article we …
“The 49, XXXXY karyotype is the rarest form of chromosomal condition or aneuploidy occurring mostly in males due to the event known as non-disjunction.” Or we can say, A type of aneuploidy, 49, XXXXY is a kind of chromosomal abnormality occurring by the presence of three extra chromosomes in a male. The addition or deletion …