Month: August 2020

In which conditions a Karyotyping or a Karyotype Test is preferred?

Karyotyping is a type of genetic test prescribed during the special pregnancy cases to evaluate chromosomes.  A type of genetic test- karyotyping is prescribed during the pregnancy and some cases of having a history of genetic abnormalities.  A karyotyping, popularly known as a karyotype test is usually employed to evaluate chromosomal abnormalities. Unfortunately not so …

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The procedure of fetal karyotyping.

The Procedure of Fetal Karyotyping

The fetal karyotyping is performed in order to evaluate the chromosomal abnormalities associated with the fetus.  or When a karyotype test is performed using fetal tissue (by amniocentesis) with an objective to rule out various chromosomal conditions before birth, the whole technique is known as a fetus or fetal karyotyping.  The most trusted, versatile and …

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Comparison Between Karyotyping and Microarray

A karyotyping is a conventional cytogenetic technique that visualizes the chromosomes whilst the microarray is a molecular cytogenetic technique that analyses the chromosomes. The cytogenetic techniques rely on the study of chromosomes either structure or numbers. Changes in any of the properties of chromosomes create phenotypic variation.  For instance, we humans have 23 pairs of …

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Why are we use Pre-chilled Slides in karyotyping?

The pre-chilled slides burst chromosomes faster during the karyotyping.  If you are here, trust me you haven’t found any sustancial answer for why the ‘the pre-chilled’ slides? I can imagine that you want to optimize your karyotyping protocol rather than performing it, which means you are not looking for steps and procedures of how the …

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Which Cell Division Phase is Best for Karyotyping?

Which Cell Division Phase is Best for Karyotyping?

Karyotyping is a process of seeing chromosomes in order to know abnormalities related to it. The metaphase chromosomes are most separatable and visible.  Abnormalities in DNA or chromosomes can cause severe mental, physical or developmental disabilities. In order to find out the alteration related to chromosomes, we have to perform the cytogenetic analysis while to …

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Role of colchicine in karyotyping

Colchicine- A Mitotic Inhibitor in Karyotyping

“Mitotic inhibitor halts cell division during karyotyping in order to get separated chromosomes. Colchicine is a common mitotic inhibitor used in cytogenetic techniques like karyotyping.” Cytogenetic techniques are used to study cell and related components. Karyotyping is a method used to analyze chromosomes during cell division hence consider as cytogenetic technique.  To get good chromosomes …

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What are Mitogens? How is it Important in Karyotyping?

What are Mitogens? How is it Important in Karyotyping?

“Mitogens are lectins or other peptides that bind to the cell surface and induce mitotic activity and cell division.“ By using the MAPK- mitotic activated protein kinase, a signal transduction pathway induced by mitogens leads to mitosis. The mitogens are potent endogenous or exogenous agents facilitating cell division by increasing mitotic activity.  But what is …

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