December 2020

What is Chromosomal Translocation?- Definition, Mechanism and Types

When a part of chromosome breaks or is deleted and reinserted at another location on a chromosome is known as a chromosome translocation. Conventional karyotyping is a technique commonly employed to study translocations.  Any sudden change, alteration or undesirable alteration in a gene or chromosome might be harmful to our health. “Mutation” is a common …

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Type of Chromosomes in Normal Karyotype- Metacentric, Acrocentric and Telocentric Chromosomes

Metacentric, Acrocentric and Telocentric Chromosomes

A Cytogenetic technique is known as karyotyping determines the number and structure of chromosomes. Based on the size and shape of chromosomes and location of the centromere it is divided into metacentric, acrocentric, telocentric types.  Two important parts of chromosomes are the arms and the centromere. The location of the centromere varies from chromosome to …

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Limitations of Karyotyping- What can’t be detected?

“Karyotyping is a technique based on cell culture; employed to detect chromosomal alterations but can’t detect variations at the DNA level.”  Karyotyping is a very traditional, manual and primitive technique, employed in recent times too for the detection of various genetic anomalies. Genetic problems/diseases or anomalies are arisen due to mutations/alterations or variations in either …

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