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By Dr Tushar Chauhan October 16, 2022
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P53 is a tumor suppressor gene located on chromosome 17 and is involved in 60% of different cancers.
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Breast cancer-associated gene 1 is located on chromosome 17 and is involved in inherited breast cancer. It’s a dominant breast cancer marker.
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Breast cancer-associated gene 2 is located on chromosome 13 and is involved in inherited breast cancer. BRCA2 is another common breast cancer marker.
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Phosphate and TENsin homolog deleted on chromosome 10 is a tumor suppressor gene, located on chromosome 10. It has known involvement in many cancers including breast cancer.
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Adenomatous Polyposis Coli (APC) is a tumor suppressor gene and located on chromosome 5. It causes colon and rectal cancer.
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RAS family genes (KRAS, HRAS and NRAS) are proto-oncogenes. They have involvement in many types of cancer including pancreatic, colorectal and lung cancer.
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The ABL-1 gene is located on chromosome 9 and is a tumor suppressor gene. It’s a classic marker for Chronic Myeloid Leukemia.
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The BCR gene is located on chromosome 22. The BCR-ABL1 gene fusion is a classic cytogenetic marker for CML.
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The CHEK 2 (Checkpoint Kinase 2) gene is located on chromosome 12 and is a tumor suppressor gene. It has involvement in colon and rectal cancer.
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The ATM (Ataxia telangiectasia mutated) gene is located on chromosome 11. It causes breast cancer.
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