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By Dr Tushar Chauhan September 24, 2022
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The process of altering a DNA or gene for a purpose, usually, performed to alter gene function is gene therapy.
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In 1990, French Anderson performed the world’s first successful gene therapy against several combined immuno-defects.
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It allows us to replace, repair or remove a faulty gene and helps restore the same gene's normal function.
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When gene therapy is performed on somatic cells of the organism. It’s effectual only on cells or tissues altered.
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When gene therapy is performed on germ cells (egg or sperm). It is inherited and alters all the cells.
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Suicide gene therapy induce apoptosis of tumor cells by introducing a transgene. Such therapies prevent tumorogenesis.
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Faulty genes can be deactivated or silenced by the gene inhibition approach. It suppresses a gene.
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A new protein-coding gene is inserted into a target cell by gene augmentation. This approach is popular for treating monogentic disease.
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When a gene is introduced directly into the body or tissue by intravenous way. This approach is tissue specific.
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When gene therapy is performed in a laboratory on a cell line or isolated cells. This therapeutic approach is safe.
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